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Medical Food Designed to Support and Protect the Mitochondrial Function of

Optic Nerve Cells in Patients with Glaucoma

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Study Results

A Randomized, Double-masked, Placebo-controlled Trial of the Efficacy of a Novel Neuroprotective Combination for Reversing Mitochondrial Dysfunction in Glaucoma

Robert Ritch, M.D., New York Eye and Ear Infirmary, New York, NY, United States

Yanin Dr. Suwan, Department of Ophthalmology, Ramathibodi Hospital, Bangkok, Thailand

Richard B. Rosen, M.D., New York Eye and Ear Infirmary, New York, NY, United States

C. Gustavo De Moraes, M.D., MPH, Columbia University Medical Center, New York, NY, United States


To determine whether a combination of anti-oxidant and mitoprotective properties could reverse mitochondrial dysfunction in treated glaucoma patients by reducing mitochondrial flavoprotein fluorescence compared to placebo.


Retinal Metabolic Analysis (RMA) measures mitochondrial flavoprotein fluorescence (aFPF) and its average curve width (ACW), which are markers of mitochondrial oxidative stress. Twenty patients were randomized into two group: 1) placebo and 2) a combination of curcumin, Ginkgo biloba extract, citicoline, coenzyme-Q10 (ubiquinol, Cognizin™), N-acetyl-cysteine, alpha-lipoic acid, grape seed extract, and green tea extract (Glaucohealth™)*. The study was performed under an IND from the FDA. Patients were tested with visual fields (VF), optical coherence tomography (OCT), and the retinal metabolic analyzer (RMA) at baseline, 1, and 3 months after randomization. Hierarchical mixed effects linear models tested for changes in VF, OCT, and RMA indices over time.


There were no significant changes in VF (MD, PSD) or OCT (macular RGC) indices in either group (all P>5%). There was a significant decrease in optic nerve aFPF and ACW from baseline to 1 month in patients treated with GlaucoHealth™* (β=-39, P=0.003; β=-25, P=0.01; respectively) but not in patients treated with placebo (p=0.47 and 0.30).


Mitochondrial dysfunction and death are increasingly implicated in retinal ganglion cell death in glaucoma and neuronal death in other neurodegenerative disorders. Glaucoma can develop and progress with low intraocular pressure. Formulations with IOP-independent neuroprotective effects could be additive in slowing progression rates by reversing mitochondrial dysfunction. A combination of mitochondrial protectants and anti-oxidants (GlaucoHealth™)* reversed mitochondrial metabolic dysfunction measures with RMA. This finding serves as a proof-of-concept for future trials testing the neuroprotective effect of micro nutrient combinations in glaucoma.


GlaucoHealth™* reverses mitochondrial dysfunction and may be neuroprotective in glaucoma. This finding serves as a proof-of-concept for future trials testing the neuroprotective effect of micro nutrient combinations in glaucoma.


  1. Field MG, Yang D, Bian ZM, et al. Retinal flavoprotein correlates with mitochondrial stress, apoptosis, and chemokine expression. Exp Eye Res 2011; 93: 548-55.
  1. Osborne NN, Álvarez CN, del Olmo Aguado S. Targeting mitochondrial dysfunction as in aging and glaucoma. Drug Discov Today. 2014 Oct; 19(10): 1613-22.
  1. Lee D, Shim MS, Kim KY et al. Coenzyme Q10 inhibits glutamate excitotoxicity and oxidative stress-mediated mitochondrial alteration in a mouse model of glaucoma. Invest Ophthalmol Vis Sci 2014; 55: 993-1005.

Glaucocetin retinal & neuroprotection medical food
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    The Precursor Compound (Glaucohealth™)* was Proven in Clinical Trials, at World-Renowned New York Eye and Ear Infirmary, to Reverse Mitochondrial Dysfunction in Glaucoma Nerve Cells

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    First Medical Food developed specifically to Reverse Damage to Glaucoma Nerve Cells caused by underlying Mitochondrial Dysfunction

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    Comes in Powder Form for Maximum Absorption

*The Precursor to GlaucoCetin, Glaucohealth™, and all related formulas created by Dr Robert Ritch were acquired by Guardion Health Sciences in the second quarter of 2018 and subsequently renamed GlaucoCetin.

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– GlaucoCetin is the first vision-specific Medical Food designed to support and protect the mitochondrial function of nerve cells in glaucoma patients.

30-Day Supply: Comes in Powder Form. 

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GlaucoCetin® is a Medical Food. In order to process your order, you will need a DAC (Doctor Authorization Code) number from your healthcare provider. If you do not have a DAC number, please call us at (800) 873-5141 Dial 1 so that we may assist you.

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